Science is the key to overcome infertility – We call it ReproScience

ReproScience is initiating over 20 new cross-border projects with more than 20 new research positions in order to overcome infertility.

ReproScience’s objective is to create a High Competence Centre in reproductive medicine. This requires an enhanced cooperation between the Danish and Swedish research groups. Therefore, we are initiating over 20 new cross-border projects during the project period with more than 20 new research positions. This will connect the Oresund region’s main competencies and strengthen the scientific quality. In the long term this will keep the region world leading in managing and preventing infertility problems.

Historically, the Oresund region – also known as Medicon Valley – has a high international position within reproductive medicine in relation to patient management and research. However, there is a need to strengthen the collaboration between the partners at hospitals, universities and industry, in order to maintain and develop the field.

ReproUnion represents more than 50 PhD students and approximately 30 senior researchers. The clinics who are partners of ReproUnion have access to large patient materials, including 4000 IVF/ICSI cycles per year, 1500 seeking andrological management and 6000 semen analyses.

The key clinical competences include:

• High standard IVF and ICSI treatment including use of recent methods for embryo selection;
• Extended evaluation of the male partner in order to find the best treatment options for the couple and prevent long term squeal of infertility;
• Sperm DNA analysis;
• Andrological surgery and treatment of ejaculatory dysfunction;
• Gonadal cryopreservation;
• Gamete donation;
• Assessment and counselling regarding environmental reproductive risks at the individual and the group level

With these competences, we are able to overcome infertility together.

Watch the videos with the senior researchers and learn more about their visions for the ReproUnion project.

Overview of ReproScience projects

The following science projects are currently under development within the ReproUnion framework. Click on a project title to read more about each project.

Click here to browse the graphical list of project.

Project	ID	PhD/PostDoc	Principal Investigater	Organisation
Fetal Programming of Semen quality	BBH1	Katia Keglberg Haervig and Birgit Høyer	Jens Peter Bonde and Elvira Vaclavik Bräuner	Bispebjerg Hospital Department of Occupational and Environmental Medicine
Male and female infertility as a precursor of chronic disease and mortality	BBH2	Clara Helene Glazer	Jens Peter Bonde and Elvira Vaclavik Bräuner	Bispebjerg Hospital Department of Occupational and Environmental Medicine
Reducing the Impact of Ovarian sTimulation – RIOT A	HER1	Agnieszka Warzecha	Sven O. Skouby	Herlev Hospital Department of Gynaecology and Obstetrics
Reducing the Impact of Ovarian sTimulation – RIOT B	HER2	Agnieszka Warzecha	Sven O. Skouby	Herlev Hospital Department of Gynaecology and Obstetrics
Age and follicle DNA methylation profile	HER3	Kristina Wendelboe Olsen	Marie Louise Grøndahl	Herlev Hospital Department of Gynaecology and Obstetrics
Surgical sperm retrieval in non-obstructive azoospermic men – a randomized trial	HER4	Christian Fuglesang S. Jensen	Jens Sønksen	Herlev Hospital Department of Urology
Identification of ovulation related genes and pathways in human follicles at different stages of oocyte maturation	HOL1	Liv la Cour Poulsen	Anne Lis Mikkelsen Englund	Holbæk Sygehus The Fertility Clinic
Epigenetic biomarkers for metabolic syndrome in women with Polycystic Ovary Syndrome	HOL2	Pernille Bækgaard Udesen	Anne Lis Mikkelsen Englund	Holbæk Sygehus The Fertility Clinic
Freeze all and transfer later	HVI1	Sacha Stormlund	Anja Pinborg	Hvidovre Hospital Department of Gynaecology and Obstetrics
The association between fetal exposure to endocrine disrupters cerebral palsy	LUND1	Anna Jöud and Andrea Sehlstedt	Lars Rylander	Lund University Department of Occupational and Environmental Medicine
The association between air pollution and preeclampsia	LUND2	Ebba Malmqvist	Ebba Malmqvist	Lund University Department of Occupational and Environmental Medicine
Testosterone proteomics study (TP study)	LUND3	Barbara Sahlin PhD	Johan Malm	Lund University Department of Clinical Chemistry Malmö
Sperm DNA strand breaks in relation to infertility treatment and the health of the	M1	Amelie Stenquist	Aleksander Giwercman	Lund University Department of Translational Medicine Malmö
Cancer treatment and genetic instability in relation to the health of the offspring	M2	Yahia Al-Jaberi	Aleksander Giwercman	Lund University Department of Translational Medicine Malmö
Stratified treatment in ovarian hyper stimulation	M3	Nishtman Dizeyi	Yvonne Lundberg Giwercman	Lund University Molecular Genetic Reproductive Medicine, Malmö
Auto-transplantation of fragmented ovarian cortical tissue in infertile patients with low ovarian reserve – a study to promote follicular activation and fertility	RH-FC1	Stine Lunding	Anders Nyboe Andersen	Rigshospitalet The Fertility Clinic
Infertility and membrane fusion – The role of Syncytin in membrane fusion of human egg and sperm cells	RH-FC2	Marie Berg Nygaard	Søren Ziebe	Rigshospitalet The Fertility Clinic
Ovarian reserve parameters in long-term combined oral contraceptive use, and knowledge and concerns about fertility after long-term use – A prospective study of Danish women	RH-FC3	Selma Kløve Landersø	Anders Nyboe Andersen	Rigshospitalet The Fertility Clinic
New method to quantify INSL3 by LC-MS/MS: A new diagnostic marker for Leydig cell function	RH-GR1	Jakob Albrethsen	Anders Juul	Rigshospitalet Department of Growth and Reproduction
Semen quality: A marker of health	RH-GR2	Lærke Priskorn	Anders Juul	Rigshospitalet Department of Growth and Reproduction
Identification of genetic and epigenetic variation influencing gonadal function	RH-GR3	Nina Mørup	Anders Juul	Rigshospitalet Department of Growth and Reproduction
The concentration of carbon fluoride and paracetamol in human embryos	RH-LRB1	Linn Salto Mamsen	Claus Yding Andersen	Rigshospitalet Laboratory of Reproductive Biology
Development of new methods to preserve fertility in pre-pubertal Danish and Swedish boys, who have a risk of a destroyed testis function	RH-LRB2	Lihua Dong	Claus Yding Andersen	Rigshospitalet Laboratory of Reproductive Biology
Growth activation of resting ovarian follicles – a novel approach for fertility treatment and preservation	RH-LRB3	Susanne Pors	Claus Yding Andersen	Rigshospitalet Laboratory of Reproductive Biology